Compound ID | 2097

Update compound information

Valnemulin

Class: Pleuromutilin

Agent Type: Semisynthetic; Small molecule; Direct acting;
Spectrum of activity: Gram-positive
Mechanism of action: Protein synthesis inhibitor. Binds to the peptidyl transferase component of the bacterial 50S ribosomal subunit, thus inhibiting peptide bond formation
Description: Semisynthetic pleuromutilin derivative. Used in veterinary medicine
Year first mentioned: 1997
Highest development stage: Approved for veterinary use
Development status: Approved
Chemical structure(s):
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Molecular weight: 564.82
Iso. SMILES: C[C@@H]1CC[C@@]23CCC(=O)[C@H]2[C@@]1([C@@H](C[C@@]([C@H]([C@@H]3C)O)(C)C=C)OC(=O)CSC(C)(C)CNC(=O)[C@@H](C(C)C)N)C
InChI Key: LLYYNOVSVPBRGV-MVNKZKPCSA-N
Can. SMILES: C=C[C@]1(C)C[C@H]([C@]2(C)[C@H](C)CC[C@]3(CCC(=O)[C@@H]23)[C@@H](C)[C@@H]1O)OC(=O)CSC(C)(C)CNC(=O)[C@@H](C(C)C)N
InChI: InChI=1S/C31H52N2O5S/c1-10-29(8)15-22(38-23(35)16-39-28(6,7)17-33-27(37)24(32)18(2)3)30(9)19(4)11-13-31(20(5)26(29)36)14-12-21(34)25(30)31/h10,18-20,22,24-26,36H,1,11-17,32H2,2-9H3,(H,33,37)/t19-,20+,22-,24-,25+,26+,29-,30+,31+/m1/s1
External links:
PubChem link: https://pubchem.ncbi.nlm.nih.gov/compound/9850878
Guide to Pharmacology: valnemulin
Citations:
  • https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1426994/
  • https://academic.oup.com/jac/article/69/8/2022/873861

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