Valnemulin

Class: Pleuromutilin

Spectrum of activity:	Gram-positive
Details of activity:	Binds to the peptidyl transferase component of the 50S subunit of ribosomes, thus inhibiting peptide bond formation. Active against Gram-positive bacteria.
Description:	Semisynthetic pleuromutilin derivative. Used in veterinary medicine
Year first mentioned:	1997
Development status:	Approved for veterinary use off-patent

Chemical structure(s):
Canonical SMILES:	C=C[C@]1(C)C[C@H]([C@]2(C)[C@H](C)CC[C@]3(CCC(=O)[C@@H]23)[C@@H](C)[C@@H]1O)OC(=O)CSC(C)(C)CNC(=O)[C@@H](C(C)C)N
Isomeric SMILES:	C[C@@H]1CC[C@@]23CCC(=O)[C@H]2[C@@]1([C@@H](C[C@@]([C@H]([C@@H]3C)O)(C)C=C)OC(=O)CSC(C)(C)CNC(=O)[C@@H](C(C)C)N)C
InChI:	InChI=1S/C31H52N2O5S/c1-10-29(8)15-22(38-23(35)16-39-28(6,7)17-33-27(37)24(32)18(2)3)30(9)19(4)11-13-31(20(5)26(29)36)14-12-21(34)25(30)31/h10,18-20,22,24-26,36H,1,11-17,32H2,2-9H3,(H,33,37)/t19-,20+,22-,24-,25+,26+,29-,30+,31+/m1/s1
InChI Key:	LLYYNOVSVPBRGV-MVNKZKPCSA-N
Structure link:	https://pubchem.ncbi.nlm.nih.gov/compound/9850878

External links:
Main Source:	https://academic.oup.com/jac/article/69/8/2022/873861
Citation:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1426994/