Compound ID | 2115

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Thiotetromycin

Class: Natural product antibiotic

Agent Type: Natural product; Small molecule; Direct acting;
Spectrum of activity: Gram-negative
Mechanism of action: Fatty acid synthesis inhibitor. Binds FabH, FabB and FabF; FabH/ FabB/ FabF inhibitor
Target Pathogen: Active against Escherichia coli and Bacteroides fragilis
Description: Natural product produced by Streptomyces total synthesis; several analogues
Year first mentioned: 1983
Development status: Experimental
Reason dropped: Enhances ATPase activity of myosin B from skeletal muscle
Chemical structure(s):
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Molecular weight: 238.35
Iso. SMILES: CCC1=C([C@@](SC1=O)(CC)/C=C(\C)/C=C)O
InChI Key: GUYLXXKTXNVUKW-MMQHEFTJSA-N
Can. SMILES: C=C/C(=C/[C@]1(CC)C(=C(CC)C(=O)S1)O)/C
InChI: InChI=1S/C13H18O2S/c1-5-9(4)8-13(7-3)11(14)10(6-2)12(15)16-13/h5,8,14H,1,6-7H2,2-4H3/b9-8+/t13-/m1/s1
External links:
PubChem link: https://pubchem.ncbi.nlm.nih.gov/compound/135754258
Citations:
  • https://pubs.rsc.org/en/content/articlelanding/2019/ob/c8ob03109f
  • https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6437001/
  • https://www.jstage.jst.go.jp/article/antibiotics1968/36/2/36_2_109/_pdf/-char/en

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