Compound ID | 2116

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Thiolactomycin

Class: Natural product antibiotic

Spectrum of activity: Gram-negative
Details of activity: Inhibits fatty acid synthesis by binding to FabB and FabF. Activity against E. coli.
Description: Natural product produced by Streptomyces and Nocardia; total synthesis, several analogues; researched for anticancer treatment
Year first mentioned: 1981
Development status: Experimental
Chemical structure(s):
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Molecular weight: 210.29
Iso. SMILES: CC1=C([C@@](SC1=O)(C)/C=C(\C)/C=C)O
InChI Key: SYQNUQSGEWNWKV-XUIVZRPNSA-N
Can. SMILES: C=C/C(=C/[C@]1(C)C(=C(C)C(=O)S1)O)/C
InChI: InChI=1S/C11H14O2S/c1-5-7(2)6-11(4)9(12)8(3)10(13)14-11/h5-6,12H,1H2,2-4H3/b7-6+/t11-/m1/s1
External links:
PubChem link: https://pubchem.ncbi.nlm.nih.gov/compound/135403829
Citations:
  • https://pubmed.ncbi.nlm.nih.gov/11591436/
  • https://pubs.acs.org/doi/abs/10.1021/jm049389h
  • https://www.jstage.jst.go.jp/article/antibiotics1968/35/4/35_4_391/_pdf

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