Compound ID | 2117

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Thiotetroamide

Class: Natural product antibiotic

Agent Type: Natural product; Small molecule; Direct acting;
Spectrum of activity: Gram-negative
Mechanism of action: Fatty acid synthesis inhibitor. Binds to FabB and FabF; FabB/ FabF inhibitor
Target Pathogen: Active against Escherichia coli
Description: Natural product produced by Streptomyces; total synthesis
Year first mentioned: 1988
Development status: Experimental
Chemical structure(s):
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Molecular weight: 267.35
Iso. SMILES: CCC1=C([C@@](/C=C(/C=C)\C)(SC1=O)CC(N)=O)O
InChI Key: GNZUNOUXZMJOPW-CFNZNRNTSA-N
Can. SMILES: C=C/C(=C/[C@]1(CC(=O)N)C(=C(CC)C(=O)S1)O)/C
InChI: InChI=1S/C13H17NO3S/c1-4-8(3)6-13(7-10(14)15)11(16)9(5-2)12(17)18-13/h4,6,16H,1,5,7H2,2-3H3,(H2,14,15)/b8-6+/t13-/m0/s1
External links:
Citations:
  • https://pubmed.ncbi.nlm.nih.gov/11591436/
  • https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6437001/

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