Compound ID | 2121

Update compound information

IMB-H4

Class: Small molecule antibacterial agent

Agent Type: Synthetic; Small molecule; Direct acting;
Spectrum of activity: Gram-negative
Mechanism of action: Membrane-active agent. Inhibits BamA-BamD interaction by binding to BamA of the of the beta-barrel folding complex (BAM), thus impairs the outer membrane integrity and decreases the abundance of outer membrane proteins
Description: Synthetic compound; derivative of 5-nitrofuran (nitrofurane)
Year first mentioned: 2020
Development status: Experimental
Chemical structure(s):
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Molecular weight: 393.42
Iso. SMILES: CC(C)N1CCC2=C(C1)SC(=C2C(=O)OC)NC(=O)C3=CC=C(O3)[N+](=O)[O-]
InChI Key: JMDRJNKTQIRTJV-UHFFFAOYSA-N
Can. SMILES: CC(C)N1CCC2=C(C1)SC(=C2C(=O)OC)NC(=O)C3=CC=C([N+](=O)[O-])O3
InChI: InChI=1S/C17H19N3O6S/c1-9(2)19-7-6-10-12(8-19)27-16(14(10)17(22)25-3)18-15(21)11-4-5-13(26-11)20(23)24/h4-5,9H,6-8H2,1-3H3,(H,18,21)
External links:
PubChem link: https://pubchem.ncbi.nlm.nih.gov/compound/5215006
Citations:
  • https://www.frontiersin.org/articles/10.3389/fmicb.2020.01252/full
  • https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7316895/

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