Compound ID | 214

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MAC-0045389

Class: Small molecule antibacterial agent

Agent Type: Synthetic; Small molecule; Direct acting;
Spectrum of activity: Gram-positive
Mechanism of action: Cell wall synthesis inhibitor. Detected by cell wall inhibitor reporter system; shows weak whole cell activity
Description: Synthetic compound from Chembridge and Maybridge Chemicals compound collection
Institute where first reported: Department of Biochemistry and Biomedical Sciences and Michael G. DeGroote Institute of Infectious Disease Research, McMaster University, Hamilton, Ontario, Canada
Year first mentioned: 2014
Development status: Experimental
Chemical structure(s):
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Molecular weight: 308.38
Iso. SMILES: CC1=C(C=C(O1)C(C)(C)C)C(=O)/C(=C/NC2=CC=CC=C2)/C#N
InChI Key: HKVPUUGOUUPQFK-WYMLVPIESA-N
Can. SMILES: CC1=C(C=C(C(C)(C)C)O1)C(=O)/C(=C/NC2=CC=CC=C2)/C#N
InChI: InChI=1S/C19H20N2O2/c1-13-16(10-17(23-13)19(2,3)4)18(22)14(11-20)12-21-15-8-6-5-7-9-15/h5-10,12,21H,1-4H3/b14-12+
External links:
Structure link: https://pubchem.ncbi.nlm.nih.gov/compound/2742210
Citations:
  • http://aac.asm.org/content/58/6/3261.full
  • https://journals.asm.org/doi/full/10.1128/aac.02352-14

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