Compound ID | 2141

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AM-8085

Class: Small molecule antibacterial agent

Spectrum of activity: Gram-positive
Details of activity: Binds to type II topoisomerases, gyrase and topoisomerase IV and thus, inhibits DNA cleavage and ligation reactions. Activity against mainly Gram-positive bacteria.
Description: Synthetic compound; oxabicyclooctane-linked NBTI containing a pyridoxazinone and naphthyridone; enantiomers AM8191 and AM8192
Year first mentioned: 2014
Development status: Inactive
Chemical structure(s):
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Molecular weight: 494.54
Iso. SMILES: COC1=NC2=C(CC([H])C34CCC(CC3)([NH2+]CC5=NC=6NC(COC6C=C5)=O)CO4)C(F)=CN=C2C=C1
InChI Key: BCOYDHFZZXSZFA-UHFFFAOYSA-O
Can. SMILES: COC1=CC=C2C(=N1)C(=C(C=N2)F)CC([H])C34CCC(CC3)(CO4)[NH2+]CC5=CC=C6C(=N5)NC(=O)CO6
InChI: InChI=1S/C26H28FN5O4/c1-34-22-5-3-19-23(32-22)17(18(27)13-28-19)6-7-26-10-8-25(9-11-26,15-36-26)29-12-16-2-4-20-24(30-16)31-21(33)14-35-20/h2-5,13,29H,6-12,14-15H2,1H3,(H,30,31,33)/p+1
External links:
Citation: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5855675/

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