DS-2969b

Class: Bacterial topoisomerase inhibitor

Spectrum of activity:	Gram-positive
Details of activity:	Inhibits bacterial DNA gyrase (GyrB) and topoisomerase IV (ParE) by binding at the ATP-binding domain which interferes with DNA biosynthesis. Active against Gram-positive bacteria.
Description:	Synthetic compound; DS11960558 is a water-soluble prodrug
Institute where first reported:	Daiichi Sankyo
Year first mentioned:	2017
Highest developmental phase:	Phase 1
Development status:	Terminated

Chemical structure(s):
Canonical SMILES:	CCC1=C(Cl)N=C(C(=O)N[C@@H]2CCN(C[C@@H]2OC)C3=NN=C(C(C)(C)O)S3)N1
Isomeric SMILES:	CCC1=C(N=C(N1)C(=O)N[C@@H]2CCN(C[C@@H]2OC)C3=NN=C(S3)C(C)(C)O)Cl
InChI:	InChI=1S/C17H25ClN6O3S/c1-5-9-12(18)21-13(19-9)14(25)20-10-6-7-24(8-11(10)27-4)16-23-22-15(28-16)17(2,3)26/h10-11,26H,5-8H2,1-4H3,(H,19,21)(H,20,25)/t10-,11+/m1/s1
InChI Key:	RFKLYBAHWNXIDR-MNOVXSKESA-N
Structure link:	https://pubchem.ncbi.nlm.nih.gov/compound/135283668

External links:
Guide to Pharmacology:	DS-2969b
Main Source:	https://journals.asm.org/doi/10.1128/AAC.02556-17