Compound ID | 2144

Update compound information

Fascaplysin and derivatives

Class: Natural product antibiotic

Agent Type: Natural product; Small molecule; Direct acting;
Spectrum of activity: Gram-positive
Mechanism of action: Cell division inhibitor. Inhibits the Filamentous Temperature Sensitive mutant Z (FtsZ), a cytoplasmic essential protein in the cell division process; FtsZ inhibitor
Description: Natural product from marine; alkaloid analog; several pharmacological activities including antibacterial activity. High toxic potential of the natural product
Year first mentioned: 1988
Development status: Experimental
Chemical structure(s):
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Molecular weight: 306.75
Iso. SMILES: C1=CC=C2C(=C1)C3=C(N2)C4=[N+](C=C3)C5=CC=CC=C5C4=O.[Cl-]
InChI Key: PWUOOJVYZQILBG-UHFFFAOYSA-N
Can. SMILES: C1=CC2=C(C=C1)NC3=C2C=C[N+]4=C3C(=O)C5=C4C=CC=C5.[Cl-]
InChI: InChI=1S/C18H10N2O.ClH/c21-18-13-6-2-4-8-15(13)20-10-9-12-11-5-1-3-7-14(11)19-16(12)17(18)20;/h1-10H;1H
External links:
PubChem link: https://pubchem.ncbi.nlm.nih.gov/compound/73292
Citations:
  • https://pubmed.ncbi.nlm.nih.gov/35007859/
  • https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10142289/
  • https://pubmed.ncbi.nlm.nih.gov/37060755/

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