Compound ID | 2145

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DS01750413

Class: Small molecule antibacterial agent

Agent Type: Synthetic; Small molecule; Direct acting;
Spectrum of activity: Gram-positive
Mechanism of action: Cell division inhibitor. Inhibits the Filamentous Temperature Sensitive mutant Z (FtsZ), a cytoplasmic essential protein in the cell division process; FtsZ inhibitor
Description: Synthetic compound; methoxybenzamide; derivative of PC190723
Year first mentioned: 2021
Development status: Experimental
Chemical structure(s):
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Molecular weight: 488.21
Iso. SMILES: OC[C@@H](OC1=CN=CC(C(N)=O)=C1)C2=NC(C3=CC=C(OC(F)(F)F)C=C3)=C(O2)Br
InChI Key: CBGITLHJUNUNCB-CYBMUJFWSA-N
Can. SMILES: C1=CC(=CC=C1C2=C(Br)OC(=N2)[C@@H](CO)OC3=CC(=CN=C3)C(=O)N)OC(F)(F)F
InChI: InChI=1S/C18H13BrF3N3O5/c19-15-14(9-1-3-11(4-2-9)30-18(20,21)22)25-17(29-15)13(8-26)28-12-5-10(16(23)27)6-24-7-12/h1-7,13,26H,8H2,(H2,23,27)/t13-/m1/s1
External links:
Citations:
  • https://febs.onlinelibrary.wiley.com/doi/full/10.1111/febs.15489
  • https://academic.oup.com/jac/article/76/11/2867/6350072

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