Compound ID | 2147
Macolacin and analogues
Class: Polymyxin
| Spectrum of activity: | Gram-negative |
| Details of activity: | Disrupts the outer membrane by direct interaction with the lipid A component of the LPS and and disrupts the physical integrity of the phospholipid bilayer of the inner membrane, and possibly additional modes of action. Active against Gram-negative bacteria including Acinetobacter and Pseudomonas. Improved activity against mcr-1 producing strains. |
| Description: | Natural product. Discovered by predicting natural product structures; total chemical synthesis of the bioinformatically predicted biosynthetic gene cluster product. Improved analogue biphenyl-macolacin. |
| Year first mentioned: | 2022 |
| Development status: | Experimental |
| External links: | |
| Citation: | https://www.nature.com/articles/s41586-021-04264-x |
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