Compound ID | 2147
Macolacin and analogues
Class: Polymyxin
| Agent Type: | Natural product; Direct acting; |
| Spectrum of activity: | Gram-negative |
| Mechanism of action: | Membrane-active agent. Disrupts the outer membrane by direct interaction with the lipid A component of the LPS and and disrupts the physical integrity of the phospholipid bilayer of the inner membrane, and possibly additional modes of action |
| Target Pathogen: | Active against Acinetobacter sp. and Pseudomonas with improved activity against Mcr-1 producing strains |
| Description: | Natural product. Discovered by predicting natural product structures; total chemical synthesis of the bioinformatically predicted biosynthetic gene cluster product. Improved analogue biphenyl-macolacin. |
| Year first mentioned: | 2022 |
| Development status: | Experimental |
| External links: | |
| Citation: | https://www.nature.com/articles/s41586-021-04264-x |
AntibioticDB is supported by GARDP.
If you have feedback, experience problems, or are interested in a collaboration, please contact us. | Terms and conditions
The content of this site is intended for educational and scientific research purposes only and not as a source of medical advice or consultation.