Compound ID | 2148
Heteroaryl isothiazolones
Synonym(s): HITZ 1-4
Class: Small molecule antibacterial agent
| Agent Type: | Synthetic; Direct acting; |
| Spectrum of activity: | Gram-positive |
| Mechanism of action: | DNA synthesis inhibitor. Binds to type II topoisomerases, gyrase and topoisomerase IV and thus, inhibits DNA cleavage and ligation reactions; bacterial topoisomerase inhibitor |
| Description: | Synthetic compound; structural simularities to quinolones |
| Year first mentioned: | 2006 |
| Development status: | Experimental |
| External links: | |
| Citations: |
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