Compound ID | 2148

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Heteroaryl isothiazolones

Synonym(s): HITZ 1-4

Class: Small molecule antibacterial agent

Spectrum of activity: Gram-positive
Details of activity: Binds to type II topoisomerases, gyrase and topoisomerase IV and thus, inhibits DNA cleavage and ligation reactions. Activity against mainly Gram-positive bacteria.
Description: Synthetic compound; structural simularities to quinolones
Year first mentioned: 2006
Development status: Experimental
External links:
Citations:
  • https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1855488/
  • https://pubmed.ncbi.nlm.nih.gov/17228862/

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