Compound ID | 215

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RNPA 1000

Class: RnpA inhibitor

Spectrum of activity: Gram-positive
Details of activity: Staphylococcus aureus
Propensity to select resistant mutants: Yes
Institute where first reported: Department of Pathology and Microbiology, University of Nebraska Medical Center, Omaha, Nebraska, USA
Year first mentioned: 2011
Highest developmental phase: Preclinical
Development status: Active
Chemical structure(s):
Click here for structure editor
Molecular weight: 464.31
Iso. SMILES: CC1=CC(=C(N1C2=CC=C(C=C2)C(=O)O)C)/C=C(/C#N)\C(=O)NC3=CC(=CC=C3)Br
InChI Key: WQCMDUBFZYCGMI-WQRHYEAKSA-N
Can. SMILES: CC1=CC(=C(C)N1C2=CC=C(C=C2)C(=O)O)/C=C(/C#N)\C(=O)NC3=CC(=CC=C3)Br
InChI: InChI=1S/C23H18BrN3O3/c1-14-10-17(15(2)27(14)21-8-6-16(7-9-21)23(29)30)11-18(13-25)22(28)26-20-5-3-4-19(24)12-20/h3-12H,1-2H3,(H,26,28)(H,29,30)/b18-11-
External links:
Structure link: https://pubchem.ncbi.nlm.nih.gov/compound/1268986
Citations:
  • http://aac.asm.org/content/59/4/2016.full
  • https://journals.plos.org/plospathogens/article?id=10.1371/journal.ppat.1001287
  • https://journals.plos.org/plospathogens/article?id=10.1371/journal.ppat.1001287

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