Compound ID | 2150

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Amiclenomycin

Class: Antimicrobial peptide

Spectrum of activity: Gram-positive
Details of activity: Binds to biotin, causing biotin deficiency and growth inhibition; active against Mycobacterium tuberculosis
Description: Natural product produced by Streptomyces; total synthesis
Year first mentioned: 1974
Development status: Experimental
Chemical structure(s):
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Molecular weight: 196.25
Iso. SMILES: O=C(O)C(N)CCC1C=CC(N)C=C1
InChI Key: LAJWZJCOWPUSOA-UHFFFAOYSA-N
Can. SMILES: C1=CC(C=CC1CCC(C(=O)O)N)N
InChI: InChI=1S/C10H16N2O2/c11-8-4-1-7(2-5-8)3-6-9(12)10(13)14/h1-2,4-5,7-9H,3,6,11-12H2,(H,13,14)
External links:
Citations:
  • https://chemistry-europe.onlinelibrary.wiley.com/doi/abs/10.1002/jlac.198519850502
  • https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7230017/
  • https://www.semanticscholar.org/paper/Total-synthesis-of-amiclenomycin%2C-an-inhibitor-of-Mann-Carillon/34d8657d7614816887764b0f57eb08c998cbe16c
  • https://www.jstage.jst.go.jp/article/antibiotics1968/27/9/27_9_656/_pdf/-char/en

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