Compound ID | 2157

Update compound information

Paeoniflorin

Class: Drug efflux pump inhibitor

Agent Type: Natural product; Small molecule; Direct acting;
Spectrum of activity: Gram-positive
Mechanism of action: Efflux pump inhibitor. Interferes with signalling molecules in LuxS/AI-2 QS system thereby inhibiting FQ efflux pump SatAB
Target Pathogen: Active against fluoroquinolone-resistant Streptococcus suis when used with norfloxacin
Description: Natural product from Paeoniaceae plants; potentiates activity of norfloxacin against Streptococcus suis, but does not show antibacterial activity on its own
Year first mentioned: 2020
Development status: Experimental
Chemical structure(s):
Click here for structure editor
Molecular weight: 480.46
Iso. SMILES: C[C@]12C[C@@]3([C@@H]4C[C@]1([C@@]4([C@H](O2)O3)COC(=O)C5=CC=CC=C5)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O)O
InChI Key: YKRGDOXKVOZESV-WRJNSLSBSA-N
Can. SMILES: C[C@]12C[C@@]3([C@@H]4C[C@]1([C@]4(COC(=O)C5=CC=CC=C5)[C@H](O2)O3)O[C@H]6[C@@H]([C@H]([C@@H]([C@@H](CO)O6)O)O)O)O
InChI: InChI=1S/C23H28O11/c1-20-9-22(29)13-7-23(20,32-18-16(27)15(26)14(25)12(8-24)31-18)21(13,19(33-20)34-22)10-30-17(28)11-5-3-2-4-6-11/h2-6,12-16,18-19,24-27,29H,7-10H2,1H3/t12-,13-,14-,15+,16-,18+,19-,20+,21+,22-,23+/m1/s1
External links:
PubChem link: https://pubchem.ncbi.nlm.nih.gov/compound/Paeoniflorin
Citations:
  • https://ami-journals.onlinelibrary.wiley.com/toc/13652672/128/2
  • https://doi.org/10.1016/j.pharmthera.2019.107452
  • https://academic.oup.com/jac/article/77/12/3275/6730836?searchresult=1

    • AntibioticDB is supported by GARDP.

    If you have feedback, experience problems, or are interested in a collaboration, please contact us. | Terms and conditions

    The content of this site is intended for educational and scientific research purposes only and not as a source of medical advice or consultation.