Compound ID | 2158

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Compound 137

Class: Small molecule antibacterial agent

Agent Type: Synthetic; Small molecule; Direct acting;
Spectrum of activity: Gram-negative
Mechanism of action: Lipopolysaccharide synthesis inhibitor. Inhibits lipooligosaccharide phosphoethanolamine transferase A (EptA; previously LptA); EptA inhibitor
Target Pathogen: Active against Neisseria gonorrhoeae
Combined with other compounds: Yes
Description: Synthetic anti-EptA compound that ehances antibacterial activity of polymyxin B
Year first mentioned: 2022
Development status: Experimental
Chemical structure(s):
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Molecular weight: 319.4
Iso. SMILES: FC1=CC=CC=C1N2C(SCC(NC3CCCC3)=O)=NC=C2
InChI Key: ZEDKVLFJVCRZAI-UHFFFAOYSA-N
Can. SMILES: C1CCC(C1)NC(=O)CSC2=NC=CN2C3=C(C=CC=C3)F
InChI: InChI=1S/C16H18FN3OS/c17-13-7-3-4-8-14(13)20-10-9-18-16(20)22-11-15(21)19-12-5-1-2-6-12/h3-4,7-10,12H,1-2,5-6,11H2,(H,19,21)
External links:
Citation: https://academic.oup.com/jac/article/77/9/2441/6622052?searchresult=1
Patent: Australian Provisional Patent Application No. 2021903584

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