Compound ID | 2162

Update compound information

Econazole

Class: Small molecule antibacterial agent

Agent Type: Synthetic; Small molecule; Direct acting; Antibiotic adjuvant;
Spectrum of activity: Gram-positive & Gram-negative
Mechanism of action: Membrane-active agent. Causes dissipation of the bacterial membrane potential
Combined with other compounds: Yes
Description: FDA-approved imidazole-type antifungal drug reported to act synergistically with colistin against colistin-resistant bacteria; also potentiates the activity of ampicillin against select Gram-positive and Gram-negative bacteria
Year first mentioned: 2021
Development status: Experimental
Chemical structure(s):
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Molecular weight: 381.68
Iso. SMILES: C1=CC(=CC=C1COC(CN2C=CN=C2)C3=C(C=C(C=C3)Cl)Cl)Cl
InChI Key: LEZWWPYKPKIXLL-UHFFFAOYSA-N
Can. SMILES: C1=C(C=CC(=C1)Cl)COC(CN2C=CN=C2)C3=CC=C(C=C3Cl)Cl
InChI: InChI=1S/C18H15Cl3N2O/c19-14-3-1-13(2-4-14)11-24-18(10-23-8-7-22-12-23)16-6-5-15(20)9-17(16)21/h1-9,12,18H,10-11H2
External links:
PubChem link: https://pubchem.ncbi.nlm.nih.gov/compound/3198
Citations:
  • https://onlinelibrary.wiley.com/doi/10.1002/adtp.202000084#
  • https://academic.oup.com/jac/article/77/2/425/6423132?searchresult=1#332191555

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