Compound ID | 2167

Update compound information

BTZ-043

Synonym(s): benzothiazinone

Class: Small molecule antibacterial agent

Details of activity: Inhibits M. tuberculosis cell wall synthesis by blocking decaprenylphosphoryl-β-d-ribose oxidase (DprE1)
Description: Synthetic compound; a nitrobenzothiazinone
Institute where first reported: Suzhou University
Year first mentioned: 2009
Highest developmental phase: Phase 2 (NCT04044001)
Development status: Active (as of 2023)
Chemical structure(s):
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Molecular weight: 431.39
Iso. SMILES: C[C@H]1COC2(O1)CCN(CC2)C3=NC(=O)C4=C(S3)C(=CC(=C4)C(F)(F)F)[N+](=O)[O-]
InChI Key: GTUIRORNXIOHQR-VIFPVBQESA-N
Can. SMILES: C[C@H]1COC2(CCN(CC2)C3=NC(=O)C4=CC(=CC(=C4S3)[N+](=O)[O-])C(F)(F)F)O1
InChI: InChI=1S/C17H16F3N3O5S/c1-9-8-27-16(28-9)2-4-22(5-3-16)15-21-14(24)11-6-10(17(18,19)20)7-12(23(25)26)13(11)29-15/h6-7,9H,2-5,8H2,1H3/t9-/m0/s1
External links:
PubChem link: https://pubchem.ncbi.nlm.nih.gov/compound/42609849
Guide to Pharmacology: BTZ-043
Citations:
  • https://pubs.acs.org/doi/10.1021/ja211042r
  • https://www.science.org/doi/10.1126/science.1171583
  • https://www.science.org/doi/10.1126/scitranslmed.3004395
  • https://journals.asm.org/doi/10.1128/aac.01438-22
    • Patent: CN-111303075-A

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