BTZ-043

Synonym(s): benzothiazinone

Class: Nitrobenzothiazinone

Details of activity:	Inhibits M. tuberculosis cell wall synthesis by blocking decaprenylphosphoryl-β-d-ribose oxidase (DprE1)
Description:	Synthetic compound
Institute where first reported:	Suzhou University
Year first mentioned:	2009
Highest developmental phase:	Phase 2 (NCT04044001)
Development status:	Active (as of 2023)

Chemical structure(s):
Canonical SMILES:	C[C@H]1COC2(CCN(CC2)C3=NC(=O)C4=CC(=CC(=C4S3)[N+](=O)[O-])C(F)(F)F)O1
Isomeric SMILES:	C[C@H]1COC2(O1)CCN(CC2)C3=NC(=O)C4=C(S3)C(=CC(=C4)C(F)(F)F)[N+](=O)[O-]
InChI:	InChI=1S/C17H16F3N3O5S/c1-9-8-27-16(28-9)2-4-22(5-3-16)15-21-14(24)11-6-10(17(18,19)20)7-12(23(25)26)13(11)29-15/h6-7,9H,2-5,8H2,1H3/t9-/m0/s1
InChI Key:	GTUIRORNXIOHQR-VIFPVBQESA-N
Structure link:	https://pubchem.ncbi.nlm.nih.gov/compound/42609849

External links:
Guide to Pharmacology:	BTZ-043
Main Source:	https://journals.asm.org/doi/10.1128/aac.01438-22
Citations:	https://pubs.acs.org/doi/10.1021/ja211042r https://www.science.org/doi/10.1126/science.1171583 https://www.science.org/doi/10.1126/scitranslmed.3004395
Patent:	CN-111303075-A