Compound ID | 2169

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T405

Class: Beta-lactam

Agent Type: Semisynthetic; Small molecule; Direct acting;
Spectrum of activity: Antimycobacterial
Mechanism of action: Cell wall synthesis inhibitor
Target Pathogen: Active against Mycobacteroides abscessus
Propensity to select resistant mutants: Yes
Description: Synthetic compound built upon a penem core
Year first mentioned: 2020
Development status: Experimental
Chemical structure(s):
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Molecular weight: 387.5
Iso. SMILES: C[C@@H](O)[C@H]1C(N2[C@@H]1SC(SC3CN(C4=[NH+]CCS4)C3)=C2C([O-])=O)=O
InChI Key: CBGHZVLFFMWIIR-CDOJRTKCSA-N
Can. SMILES: C[C@H]([C@H]1C(=O)N2C(=C(SC3CN(C3)C4=[NH+]CCS4)S[C@H]12)C(=O)[O-])O
InChI: InChI=1S/C14H17N3O4S3/c1-6(18)8-10(19)17-9(12(20)21)13(24-11(8)17)23-7-4-16(5-7)14-15-2-3-22-14/h6-8,11,18H,2-5H2,1H3,(H,20,21)/t6-,8+,11-/m1/s1
External links:
Citations:
  • https://www.nature.com/articles/s42003-020-01475-2
  • https://journals.asm.org/doi/10.1128/aac.00536-22

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