Compound ID | 2171

Update compound information

EC/11716

Class: DNA synthesis inhibitor

Details of activity: Active against nontuberculous Mycobacterium
Propensity to select resistant mutants: Yes
Description: Shows activity against M. abscessus subspecies and clinical isolates (including in biofilms)
Year first mentioned: 2021
Development status: Experimental
Chemical structure(s):
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Molecular weight: 457.95
Iso. SMILES: O=C1N(CCN2CCC(NCC3=CN=C(CO)C(Cl)=C3)CC2)C4=C(C=C1)N=CC(=C4)OC
InChI Key: KVYWHGHYFLQLQJ-UHFFFAOYSA-N
Can. SMILES: COC1=CN=C2C=CC(=O)N(CCN3CCC(CC3)NCC4=CN=C(CO)C(=C4)Cl)C2=C1
InChI: InChI=1S/C23H28ClN5O3/c1-32-18-11-22-20(27-14-18)2-3-23(31)29(22)9-8-28-6-4-17(5-7-28)25-12-16-10-19(24)21(15-30)26-13-16/h2-3,10-11,13-14,17,25,30H,4-9,12,15H2,1H3
External links:
Citations:
  • https://journals.asm.org/doi/10.1128/AAC.03913-14
  • https://journals.asm.org/doi/10.1128/AAC.01514-21

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