Compound ID | 2173
MRX-6038
Class: Small molecule antibacterial agent
| Agent Type: | Synthetic; Direct acting; |
| Spectrum of activity: | Antimycobacterial |
| Mechanism of action: | Protein synthesis inhibitor. Aminoacyl-tRNA synthetase inhibitor (leucyl-tRNA synthetase [LeuRS] inhibitor) |
| Target Pathogen: | Active against nontuberculosis mycobacteria |
| Propensity to select resistant mutants: | Yes |
| Description: | Synthetic boron containing compound; synergistic activity with macrolides |
| Institute where first reported: | MicuRx Pharmaceuticals |
| Year first mentioned: | 2022 |
| Development status: | Experimental |
| External links: | |
| Citation: | https://journals.asm.org/doi/10.1128/aac.00601-22 |
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