Compound ID | 2175

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Negamycin

Class: Antimicrobial peptide

Agent Type: Natural product; Small molecule; Direct acting;
Spectrum of activity: Gram-positive & Gram-negative
Mechanism of action: Protein synthesis inhibitor. Inhibits translation and triggers misreading by establishing contacts with the aminoacyl-tRNA and increasing the residency time of noncognate tRNAs
Description: Natural product from Streptomyces purpeofuscus; pseudopeptide with hydroxy-β-lysine as the central amino acid
Year first mentioned: 1970
Development status: Experimental
Chemical structure(s):
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Molecular weight: 248.28
Iso. SMILES: CN(CC(=O)O)NC(=O)C[C@@H](C[C@H](CN)O)N
InChI Key: IKHFJPZQZVMLRH-RNFRBKRXSA-N
Can. SMILES: CN(CC(=O)O)NC(=O)C[C@@H](C[C@H](CN)O)N
InChI: InChI=1S/C9H20N4O4/c1-13(5-9(16)17)12-8(15)3-6(11)2-7(14)4-10/h6-7,14H,2-5,10-11H2,1H3,(H,12,15)(H,16,17)/t6-,7-/m1/s1
External links:
PubChem link: https://pubchem.ncbi.nlm.nih.gov/compound/11118411
Citation: https://journals.asm.org/doi/10.1128/aac.00986-20

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