Compound ID | 2180

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PBT2

Class: Small molecule antibacterial agent

Spectrum of activity: Gram-positive  &  Gram-negative
Details of activity: Active against Neisseria gonorrhoeae and N. meningitidis even without zinc; believed to perturb metal (iron) homeostasis
Propensity to select resistant mutants: No
Description: An ionophore; currently on Phase 2 clinical trials for potential use in Alzheimer's and Huntington’s diseases; shows activity against Gram-positive and Gram-negative bacteria in the presence of zinc
Year first mentioned: 2005
Development status: Experimental
Chemical structure(s):
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Molecular weight: 271.14
Iso. SMILES: CN(C)CC1=NC2=C(C=C1)C(=CC(=C2O)Cl)Cl
InChI Key: YZPOQCQXOSEMAZ-UHFFFAOYSA-N
Can. SMILES: CN(C)CC1=CC=C2C(=CC(=C(C2=N1)O)Cl)Cl
InChI: InChI=1S/C12H12Cl2N2O/c1-16(2)6-7-3-4-8-9(13)5-10(14)12(17)11(8)15-7/h3-5,17H,6H2,1-2H3
External links:
PubChem link: https://pubchem.ncbi.nlm.nih.gov/compound/10016012
Citation: https://journals.asm.org/doi/10.1128/aac.02318-21

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