Compound ID | 2182

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TBI-166

Synonym(s): Pyrifazimine

Class: Small molecule antibacterial agent

Details of activity: Active against Mycobacterium sp.
Description: Synthetic compound derived from optimization of riminophenazine analogues
Institute where first reported: Institute of Materia Medica of the Chinese Academy of Medical Sciences
Year first mentioned: 2012
Highest developmental phase: Phase 2 (NCT04670120)
Development status: Active (as of 2023)
Chemical structure(s):
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Molecular weight: 589.61
Iso. SMILES: COC1CCC(CC1)N=C2C=C3C(=NC4=CC=CC=C4N3C5=CC=C(C=C5)OC(F)(F)F)C=C2NC6=C(N=CC=C6)OC
InChI Key: GUSGYHIQYWRCQO-UHFFFAOYSA-N
Can. SMILES: COC1CCC(CC1)N=C2C=C3C(=NC4=C(C=CC=C4)N3C5=CC=C(C=C5)OC(F)(F)F)C=C2NC6=CC=CN=C6OC
InChI: InChI=1S/C32H30F3N5O3/c1-41-22-13-9-20(10-14-22)37-27-19-30-28(18-26(27)39-25-7-5-17-36-31(25)42-2)38-24-6-3-4-8-29(24)40(30)21-11-15-23(16-12-21)43-32(33,34)35/h3-8,11-12,15-20,22,39H,9-10,13-14H2,1-2H3
External links:
PubChem link: https://pubchem.ncbi.nlm.nih.gov/compound/53377576
Guide to Pharmacology: TBI-166
Citations:
  • https://journals.asm.org/doi/10.1128/AAC.00699-11
  • https://journals.asm.org/doi/10.1128/aac.00658-22
    • Patent: WO2012003190A1

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