Compound ID | 2183

Update compound information

TPP8

Class: Small molecule antibacterial agent

Details of activity: Active against Mycobacterium abscessus and M. tuberculosis; inhibits ATPase of DNA gyrase
Propensity to select resistant mutants: Yes
Description: Synthetic compound
Year first mentioned: 2022
Development status: Experimental
Chemical structure(s):
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Molecular weight: 482.49
Iso. SMILES: FC1=CC(NC)=C2C(C3=C(N2)N=C(OC4=CN=C(N=C4)[C@H](C)O)N=C3N5CC6(C5)[C@H](CC6)N)=C1F
InChI Key: CDFOKKQJLLEEPZ-HZMBPMFUSA-N
Can. SMILES: C[C@@H](C1=NC=C(C=N1)OC2=NC(=C3C4=C(C(=CC(=C4F)F)NC)NC3=N2)N5CC6(CC[C@@H]6N)C5)O
InChI: InChI=1S/C23H24F2N8O2/c1-10(34)19-28-6-11(7-29-19)35-22-31-20-16(15-17(25)12(24)5-13(27-2)18(15)30-20)21(32-22)33-8-23(9-33)4-3-14(23)26/h5-7,10,14,27,34H,3-4,8-9,26H2,1-2H3,(H,30,31,32)/t10-,14-/m0/s1
External links:
Citation: https://journals.asm.org/doi/10.1128/aac.00669-22

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