Compound ID | 2185

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CUO246

Class: Small molecule antibacterial agent

Agent Type: Synthetic; Small molecule; Direct acting;
Spectrum of activity: Gram-positive & Gram-negative
Mechanism of action: DNA synthesis inhibitor. Inhibits the DNA gyrase (GyrAB) and topoisomerase IV (ParCE); bacterial topoisomerase inhibitor
Propensity to select resistant mutants: Yes
Description: Synthetic compound; optimised from a series of compounds that incorporates features based on fluoroquinolones and Pfizer's quinazolinediones
Year first mentioned: 2022
Development status: Experimental
Chemical structure(s):
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Molecular weight: 387.41
Iso. SMILES: NC1([C@H]2CCN(C2)C3=C(C=C4C5=C3OC[C@@H](N5C(C(C(O)=O)=C4)=O)C)F)CC1
InChI Key: KUJKUYSIFHKKCZ-JQWIXIFHSA-N
Can. SMILES: C[C@H]1COC2=C(C(=CC3=C2N1C(=O)C(=C3)C(=O)O)F)N4CC[C@@H](C4)C5(CC5)N
InChI: InChI=1S/C20H22FN3O4/c1-10-9-28-17-15-11(6-13(19(26)27)18(25)24(10)15)7-14(21)16(17)23-5-2-12(8-23)20(22)3-4-20/h6-7,10,12H,2-5,8-9,22H2,1H3,(H,26,27)/t10-,12-/m0/s1
External links:
Citations:
  • https://pubs.acs.org/doi/10.1021/acs.jmedchem.0c00347
  • https://journals.asm.org/doi/10.1128/aac.00921-22

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