Compound ID | 219

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PC190723

Synonym(s): Prodrugs TXY436 and TXY541

Class: FtsZ inhibitor

Spectrum of activity: Gram-positive
Details of activity: Inhibits the Filamentous Temperature Sensitive mutant Z (FtsZ), a cytoplasmic essential protein in the cell division process. MRSA (methicillin resistant Staphylococcus aureus)
Description: Synthetic compound; methoxybenzamide
Institute where first reported: Taxis Pharmaceuticals, Inc., North Brunswick, New Jersey, USA
Year first mentioned: 2008
Highest developmental phase: Preclinical
Development status: Inactive
Reason Dropped: Poor pharmacokinetics
Chemical structure(s):
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Molecular weight: 355.75
Iso. SMILES: C1=CC(=C(C(=C1OCC2=NC3=C(S2)N=CC(=C3)Cl)F)C(=O)N)F
InChI Key: INYJNSBDHOVLAH-UHFFFAOYSA-N
Can. SMILES: C1=C(C(=C(C(=C1)OCC2=NC3=C(N=CC(=C3)Cl)S2)F)C(=O)N)F
InChI: InChI=1S/C14H8ClF2N3O2S/c15-6-3-8-14(19-4-6)23-10(20-8)5-22-9-2-1-7(16)11(12(9)17)13(18)21/h1-4H,5H2,(H2,18,21)
External links:
PubChem link: https://pubchem.ncbi.nlm.nih.gov/compound/25016417
Citations:
  • http://aac.asm.org/content/57/12/5860.full
  • https://www.ncbi.nlm.nih.gov/pubmed/18801997

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