Compound ID | 2203

Update compound information

GT-055

Synonym(s): LCB18-055

Class: Beta-lactamase inhibitor

Spectrum of activity: Gram-negative
Details of activity: In combination with GT-1, active against Acinetobacter baumannii, Citrobacter species, Enterobacter sp., Escherichia coli, Klebsiella pneumoniae, Klebsiella sp., Kluyvera ascorbate, Morganella morganii, Proteus mirabilis, Providencia spp., Pseudomonas aeruginosa, Raoultella ornithinolytica, Salmonella spp., Serratia marcescens, Shigella sonnei
Description: Synthetic compound; shows synergistic antimicrobial effect with GT-1 (LCB10-200) against Escherichia coli, Klebsiella pneumoniae and Acinetobacter spp.
Year first mentioned: 2020
Development status: Experimental
Chemical structure(s):
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Molecular weight: 463.39
Iso. SMILES: C1C[C@H](N2C[C@@H]1N(C2=O)OS(=O)(=O)O)C3=NOC(C3)(CN)CN.C(=O)(C(F)(F)F)O
InChI Key: XGQCXSOFRKLVCG-JXLXBRSFSA-N
Can. SMILES: C1C[C@@H](C2=NOC(C2)(CN)CN)N3C[C@@H]1N(C3=O)OS(=O)(=O)O.C(=O)(C(F)(F)F)O
InChI: InChI=1S/C11H19N5O6S.C2HF3O2/c12-5-11(6-13)3-8(14-21-11)9-2-1-7-4-15(9)10(17)16(7)22-23(18,19)20;3-2(4,5)1(6)7/h7,9H,1-6,12-13H2,(H,18,19,20);(H,6,7)/t7-,9+;/m1./s1
External links:
PubChem link: https://pubchem.ncbi.nlm.nih.gov/compound/163323732
Citations:
  • https://www.mdpi.com/2079-6382/9/5/267
  • https://www.nature.com/articles/s41429-021-00472-9

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