Compound ID | 2209

Update compound information

Thiosemicarbazone

Class: Beta-lactamase inhibitor

Spectrum of activity: Gram-negative
Details of activity: Active against NDM-producing Escherichia coli
Description: Synthetic compound; can inhibit NDM-producing E. coli on its own but also shows synergistic antimicrobial effect with ampicillin, cefazolin, and meropenem to NDM-producing E. coli
Year first mentioned: 2020
Development status: Experimental
Chemical structure(s):
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Molecular weight: 236.29
Iso. SMILES: CC(=O)NC1=CC=C(C=C1)/C=N/NC(=S)N
InChI Key: SRVJKTDHMYAMHA-WUXMJOGZSA-N
Can. SMILES: CC(=O)NC1=CC=C(C=C1)/C=N/NC(=S)N
InChI: InChI=1S/C10H12N4OS/c1-7(15)13-9-4-2-8(3-5-9)6-12-14-10(11)16/h2-6H,1H3,(H,13,15)(H3,11,14,16)/b12-6+
External links:
PubChem link: https://pubchem.ncbi.nlm.nih.gov/compound/9568512
Citations:
  • https://www.nature.com/articles/s41598-020-69431-y
  • https://www.nature.com/articles/s41429-021-00440-3#Sec7

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