Compound ID | 2210

Update compound information

TXA6101

Synonym(s): TXY6129

Class: Small molecule antibacterial agent

Spectrum of activity: Gram-negative
Details of activity: Inhibits Escherichia coli FtsZ polymerization
Description: Synthetic compound from TAXIS Pharmaceuticals Inc (FtsZ-targeting molecules for Gram-positive FtsZ); compounds have lipophilic aromatic groups and halogens at the C-4 and C-5 positions of the oxazole ring which are necessary for Gram-negative activity; induced morphological changes in Escherichia coli and Klebsiella pneumoniae indicative of cell division inhibition
Year first mentioned: 2022
Development status: Experimental
Chemical structure(s):
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Molecular weight: 477.18
Iso. SMILES: C1=CC(=CC=C1C2=C(OC(=N2)COC3=C(C(=C(C=C3)F)C(=O)N)F)Br)C(F)(F)F
InChI Key: ONGPJYSSZQHFBU-UHFFFAOYSA-N
Can. SMILES: C1=C(C=CC(=C1)C(F)(F)F)C2=C(Br)OC(=N2)COC3=CC=C(C(=C3F)C(=O)N)F
InChI: InChI=1S/C18H10BrF5N2O3/c19-16-15(8-1-3-9(4-2-8)18(22,23)24)26-12(29-16)7-28-11-6-5-10(20)13(14(11)21)17(25)27/h1-6H,7H2,(H2,25,27)
External links:
PubChem link: https://pubchem.ncbi.nlm.nih.gov/compound/72947301
Guide to Pharmacology: TXA6101
Citation: https://www.nature.com/articles/s41429-022-00531-9#Abs1

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