Compound ID | 2215

Update compound information

CSA-13

Synonym(s): Cationic steroid antimicrobial 13

Class: Antimicrobial peptide

Spectrum of activity: Gram-negative
Details of activity: Active against Burkholderia sp., and disrupts Pseudomonas aeruginosa biofilm in implant related infections
Propensity to select resistant mutants: Yes
Description: Synthetic antimicrobial peptide mimic (ceragenin-type); greater antimicrobial effect when combined with levofloxacin and sulfamethoxazole-trimethoprim
Institute where first reported: George E. Wahlen Department of Veterans Affairs, Salt Lake City, Utah, USA
Year first mentioned: 2005
Development status: Experimental
Chemical structure(s):
Click here for structure editor
Molecular weight: 677.1
Iso. SMILES: CCCCCCCCNCCC[C@@H](C)[C@H]1CC[C@@H]2[C@@]1([C@H](C[C@H]3[C@H]2[C@@H](C[C@H]4[C@@]3(CC[C@H](C4)OCCCN)C)OCCCN)OCCCN)C
InChI Key: YDYLISNLJUDIGF-GXDYCHSMSA-N
Can. SMILES: CCCCCCCCNCCC[C@@H](C)[C@H]1CC[C@H]2[C@H]3[C@H](C[C@@H]([C@]12C)OCCCN)[C@@]4(C)CC[C@H](C[C@H]4C[C@H]3OCCCN)OCCCN
InChI: InChI=1S/C41H80N4O3/c1-5-6-7-8-9-10-23-45-24-11-15-31(2)34-16-17-35-39-36(30-38(41(34,35)4)48-27-14-22-44)40(3)19-18-33(46-25-12-20-42)28-32(40)29-37(39)47-26-13-21-43/h31-39,45H,5-30,42-44H2,1-4H3/t31-,32+,33-,34-,35+,36+,37-,38+,39+,40+,41-/m1/s1
External links:
PubChem link: https://pubchem.ncbi.nlm.nih.gov/compound/16678119
Citations:
  • https://academic.oup.com/jac/article/76/2/443/5936058?login=false
  • https://link.springer.com/article/10.1007/s00284-020-01949-w
  • https://journals.asm.org/doi/full/10.1128/aac.01798-13
  • https://pmc.ncbi.nlm.nih.gov/articles/PMC4576122/
  • https://academic.oup.com/jac/article/61/2/365/763272?login=true
  • https://www.nature.com/articles/s41429-022-00530-w#Sec10
    • Patent: US20210363174A1

    AntibioticDB is supported by GARDP.

    If you have feedback, experience problems, or are interested in a collaboration, please contact us. | Terms and conditions

    The content of this site is intended for educational and scientific research purposes only and not as a source of medical advice or consultation.