Compound ID | 2229

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BDM73185

Class: Drug efflux pump inhibitor

Agent Type: Synthetic; Small molecule; Direct acting;
Spectrum of activity: Gram-negative
Mechanism of action: Efflux pump inhibitor. Targets the AcrB component of the AcrAB-TolC transporter
Target Pathogen: Active against Escherichia coli
Propensity to select resistant mutants: Yes
Description: Synthetic compound (pyridylpiperazine); identified from screening assay that synergised activity of pyridomycin; also acts synergistically with chloramphenicol, tetracycline, pyridomycin, erythromycin, and ciprofloxacin; no cytotoxicity towards BALB/3T3
Year first mentioned: 2022
Development status: Experimental
Chemical structure(s):
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Molecular weight: 265.66
Iso. SMILES: ClC1=C(N2CCNCC2)N=C(C(C(F)(F)F)=C1)[H]
InChI Key: RRIPRMGRQRYRRG-UHFFFAOYSA-N
Can. SMILES: C1CN(CCN1)C2=NC([H])=C(C=C2Cl)C(F)(F)F
InChI: InChI=1S/C10H11ClF3N3/c11-8-5-7(10(12,13)14)6-16-9(8)17-3-1-15-2-4-17/h5-6,15H,1-4H2
External links:
Citations:
  • https://www.embopress.org/doi/full/10.1002/emmm.201201689
  • https://www.nature.com/articles/s41467-021-27726-2

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