Compound ID | 2233
Menaquinone Binding Antibiotic (MBA)
Class: Small molecule antibacterial agent
| Agent Type: | Semisynthetic; Direct acting; |
| Spectrum of activity: | Gram-positive & Antimycobacterial |
| Mechanism of action: | Membrane-active agent. Menaquinone binder |
| Target Pathogen: | Active against Staphylococcus aureus and Mycobacterium tuberculosis |
| Description: | Semisynthetic compound discovered by metagenomic searching of biosynthetic gene cluster predicted to encode menaquinone binders/ synthetic bioinformatic natural product (syn-BNP) |
| Year first mentioned: | 2022 |
| Development status: | Experimental |
| External links: | |
| Citation: | https://www.nature.com/articles/s41564-021-01013-8#Sec1 |
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