Compound ID | 2234

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Lawsone derivative 6c

Class: Small molecule antibacterial agent

Agent Type: Semisynthetic; Small molecule; Direct acting;
Spectrum of activity: Gram-positive
Mechanism of action: Membrane-active agent
Target Pathogen: Active against Staphylococcus aureus
Description: Synthetic compound derived from lawsone, a naturally occurring hydroxynaphthoquinone (2-hydroxy-1,4-naphthoquinone)
Year first mentioned: 2020
Development status: Experimental
Chemical structure(s):
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Molecular weight: 320.38
Iso. SMILES: OC1=C(CC2=CC=C(CCCC)C=C2)C(C3=C(C1=O)C=CC=C3)=O
InChI Key: HRRODQHMJKRWND-UHFFFAOYSA-N
Can. SMILES: CCCCC1=CC=C(C=C1)CC2=C(C(=O)C3=C(C=CC=C3)C2=O)O
InChI: InChI=1S/C21H20O3/c1-2-3-6-14-9-11-15(12-10-14)13-18-19(22)16-7-4-5-8-17(16)20(23)21(18)24/h4-5,7-12,24H,2-3,6,13H2,1H3
External links:
Citation: https://www.nature.com/articles/s42003-020-01261-0#Sec9

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