Compound ID | 2239

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Soralimixin

Synonym(s): QPX9003  |  F365  |  F 365  |  F-365

Class: Lipopeptide

Agent Type: Semisynthetic;
Spectrum of activity: Gram-negative
Mechanism of action: Unknown
Target Pathogen: Active against Pseudomonas aeruginosa and Acinetobacter baumannii
Description: Synthetic compound; rationally-designed derivative of polymyxin; reduced nephrotoxicity
Institute where first reported: Qpex Biopharma, Inc.; Brii Biosciences; Monash University
Year first mentioned: 2022
Highest development stage: Phase 1 (NCT04808414)
Development status: Active
Chemical structure(s):
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Molecular weight:
Iso. SMILES: CC[C@H]1C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)NCC[C@@H](C(=O)N[C@H](C(=O)N[C@@H](C(=O)N1)CC(C)C)CCN)NC(=O)[C@H](CN)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CCN)NC(=O)C2=C(C=C(C=C2)Cl)Cl)[C@@H](C)O)CCN)CCN
InChI Key: XRXBRIQKVLXFMJ-BCLXPCSMSA-N
Can. SMILES: CC[C@H]1C(=O)N[C@@H](CCN)C(=O)N[C@@H](CCN)C(=O)N[C@@H]([C@@H](C)O)C(=O)NCC[C@@H](C(=O)N[C@@H](CCN)C(=O)N[C@H](CC(C)C)C(=O)N1)NC(=O)[C@H](CN)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CCN)NC(=O)C2=CC=C(C=C2Cl)Cl
InChI: InChI=1S/C48H80Cl2N16O13/c1-6-28-39(70)59-29(9-14-51)40(71)61-32(12-17-54)44(75)65-36(23(4)67)47(78)56-18-13-33(42(73)60-30(10-15-52)41(72)63-34(19-22(2)3)45(76)57-28)62-46(77)35(21-55)64-48(79)37(24(5)68)66-43(74)31(11-16-53)58-38(69)26-8-7-25(49)20-27(26)50/h7-8,20,22-24,28-37,67-68H,6,9-19,21,51-55H2,1-5H3,(H,56,78)(H,57,76)(H,58,69)(H,59,70)(H,60,73)(H,61,71)(H,62,77)(H,63,72)(H,64,79)(H,65,75)(H,66,74)/t23-,24-,28+,29+,30+,31+,32+,33+,34-,35+,36+,37+/m1/s1
External links:
Structure link: https://pubchem.ncbi.nlm.nih.gov/compound/176507621
Guide to Pharmacology: soralimixin
Citation: https://www.nature.com/articles/s41467-022-29234-3

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