Compound ID | 2241

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6-thioguanine

Class: Natural product antibiotic

Spectrum of activity: Gram-positive
Details of activity: Active against Staphylococcus aureus; inhibits purine biosynthesis
Description: Natural product from Staphylococcus chromogenes ATCC43764; purine analogue produced by coagulase-negative Staphylococci; reduced skin lesion formation by Staphylococcus aureus in mice
Year first mentioned: 2021
Development status: Experimental
Chemical structure(s):
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Molecular weight: 167.19
Iso. SMILES: C1=NC2=C(N1)C(=S)N=C(N2)N
InChI Key: WYWHKKSPHMUBEB-UHFFFAOYSA-N
Can. SMILES: C1=NC2=C(C(=S)N=C(N)N2)N1
InChI: InChI=1S/C5H5N5S/c6-5-9-3-2(4(11)10-5)7-1-8-3/h1H,(H4,6,7,8,9,10,11)
External links:
PubChem link: https://pubchem.ncbi.nlm.nih.gov/compound/2723601
Citation: https://www.nature.com/articles/s41467-021-22175-3

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