Compound ID | 2244
PA-13
Class: Antimicrobial peptide
| Spectrum of activity: | Gram-positive & Gram-negative |
| Details of activity: | Active against Pseudomonas aeruginosa, Shigella sonnei, Salmonella Typhimurium, Acinetobacter baumannii, Staphylococcus epidermidis, Listeria monocytogenes; disrupts the cell membrane by pore/ion channel formation |
| Description: | Synthetic compound designed from cathelicidin and aurein; haemolytic activity in human RBCs was 2% at its MIC; low cytotoxicity to L929 cells |
| Year first mentioned: | 2020 |
| Development status: | Experimental |
| External links: | |
| Citation: | https://www.nature.com/articles/s41598-020-65688-5#Sec21 |
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