Compound ID | 225

Update compound information

Quinazoline-2,4-diamino analogue

Synonym(s): 2-({2-[(2,5-dimethylphenyl)amino]quinazolin-4-yl}amino)ethanol  |  Q24DA

Class: Antivirulence agent

Agent Type: Synthetic; Small molecule; Direct acting; Antivirulence;
Spectrum of activity: Gram-negative
Mechanism of action: Interacts with PomB to paralyze Vibrio sodium-driven polar flagellum
Target Pathogen: Active against Vibrio cholerae
Description: Synthetic compound; a quinazoline-2,4-diamino analogue
Institute where first reported: Southern Research Institute Drug Discovery Division, Birmingham, Alabama, USA
Year first mentioned: 2011
Development status: Experimental
Chemical structure(s):
Click here for structure editor
Molecular weight: 298.32
Iso. SMILES: C1=CC=C2C(=C1)C(=NC(=N2)NC3=CC=CC=C3F)NCCO
InChI Key: WXJFFRLCFBLCPN-UHFFFAOYSA-N
Can. SMILES: C1=CC2=C(NCCO)N=C(N=C2C=C1)NC3=C(C=CC=C3)F
InChI: InChI=1S/C16H15FN4O/c17-12-6-2-4-8-14(12)20-16-19-13-7-3-1-5-11(13)15(21-16)18-9-10-22/h1-8,22H,9-10H2,(H2,18,19,20,21)
External links:
Structure link: https://pubchem.ncbi.nlm.nih.gov/compound/27058259
Citations:
  • http://aac.asm.org/content/55/9/4134.full
  • http://aac.asm.org/content/57/8/3950.full
  • https://journals.asm.org/doi/full/10.1128/aac.00473-13

    • AntibioticDB is supported by GARDP.

    If you have feedback, experience problems, or are interested in a collaboration, please contact us. | Terms and conditions

    The content of this site is intended for educational and scientific research purposes only and not as a source of medical advice or consultation.