Compound ID | 2255

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DSM186

Class: Small molecule antibacterial agent

Agent Type: Synthetic; Small molecule; Direct acting;
Spectrum of activity: Gram-negative
Mechanism of action: Targets the dihydroorotate dehydrogenase (DHODH); pyrimidine synthesis inhibitor (triazolopyrimidine/ imidazopyrimidine)
Target Pathogen: Active against Acinetobacter baumannii
Description: Synthetic compound; the analogue DSM161 (lesser potency compared to DSM186) showed protection in the neutropenic mouse thigh infection model
Year first mentioned: 2022
Development status: Experimental
Chemical structure(s):
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Molecular weight: 350.31
Iso. SMILES: CC1=NC2=NC=CN2C(NC3=CC=C(S(F)(F)(F)(F)F)C=C3)=C1
InChI Key: WQQKDMYAYLYJLV-UHFFFAOYSA-N
Can. SMILES: CC1=NC2=NC=CN2C(=C1)NC3=CC=C(C=C3)S(F)(F)(F)(F)F
InChI: InChI=1S/C13H11F5N4S/c1-9-8-12(22-7-6-19-13(22)20-9)21-10-2-4-11(5-3-10)23(14,15,16,17)18/h2-8,21H,1H3
External links:
Citation: https://www.pnas.org/doi/10.1073/pnas.2213116119

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