Compound ID | 2256

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PS757

Class: Small molecule antibacterial agent

Spectrum of activity: Gram-positive
Details of activity: Active against nondividing stationary phase cells of Enterococcus faecalis
Description: Synthetic compound; peptidomimetic bicyclic central scaffold (a dihydrothiazolo ring-fused 2-pyridone with the peptidomimetic backbone); no cytotoxicity at 4xMIC (2 uM; tested until 100 uM)
Year first mentioned: 2022
Development status: Experimental
Chemical structure(s):
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Molecular weight: 555.69
Iso. SMILES: O=C1N2C(C(O)=O)=C(C3=CC=C(OCCCCCC)C(C)=C3)SC2=C(OC)C(=C1)CC4=C5C=CC=CC5=CC=C4
InChI Key: DERJCIMSBQFACB-UHFFFAOYSA-N
Can. SMILES: CCCCCCOC1=C(C)C=C(C=C1)C2=C(C(=O)O)N3C(=O)C=C(CC4=CC=CC5=C4C=CC=C5)C(=C3S2)OC
InChI: InChI=1S/C33H33NO5S/c1-4-5-6-9-17-39-27-16-15-24(18-21(27)2)31-29(33(36)37)34-28(35)20-25(30(38-3)32(34)40-31)19-23-13-10-12-22-11-7-8-14-26(22)23/h7-8,10-16,18,20H,4-6,9,17,19H2,1-3H3,(H,36,37)
External links:
Citation: https://www.pnas.org/doi/10.1073/pnas.2210912119#sec-1

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