Compound ID | 2257
Compound 10 HD5 analogue
Class: Antimicrobial peptide
| Agent Type: | Semisynthetic; Direct acting; |
| Spectrum of activity: | Gram-positive & Gram-negative |
| Mechanism of action: | Membrane-active agent. Targets OmpA beta-barrel domain and LPS lipid A domain in Gram-negative outer membrane; also targets the 70S ribosome |
| Target Pathogen: | Active against ESKAPE pathogens |
| Description: | Synthetic compound based on human defensin 5 |
| Year first mentioned: | 2022 |
| Development status: | Experimental |
| External links: | |
| Citation: | https://www.pnas.org/doi/10.1073/pnas.2117283119#sec-2 |
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