Compound ID | 2259

Update compound information

1-amino substituted tetrahydrocarbazole (THCz)

Synonym(s): THCz 1  |  THCz1

Class: Cell wall synthesis inhibitor

Agent Type: Synthetic; Small molecule; Direct acting;
Spectrum of activity: Gram-positive
Mechanism of action: Cell wall synthesis inhibitor
Target Pathogen: Active against Streptococcus pneumoniae, S. parasanguinis, S. pyogenes, S. simulans, S. epidermidis, S. aureus, E. faecalis, E. faecium
Description: Synthetic compound; small molecule targeting peptidoglycan synthesis
Year first mentioned: 2021
Development status: Experimental
Chemical structure(s):
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Molecular weight: 372.55
Iso. SMILES: C1(C2=CC3=C(NC4=C3CCCC4NCCC5=CC=CC=C5)C=C2)CCCCC1
InChI Key: UOXHIMPHQIDOBD-UHFFFAOYSA-N
Can. SMILES: C1=CC=C(C=C1)CCNC2CCCC3=C2NC4=C3C=C(C=C4)C5CCCCC5
InChI: InChI=1S/C26H32N2/c1-3-8-19(9-4-1)16-17-27-25-13-7-12-22-23-18-21(20-10-5-2-6-11-20)14-15-24(23)28-26(22)25/h1,3-4,8-9,14-15,18,20,25,27-28H,2,5-7,10-13,16-17H2
External links:
Citation: https://www.pnas.org/doi/10.1073/pnas.2108244118

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