Compound ID | 226

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DS-96

Class: Vaginal microbicide

Spectrum of activity: Gram-negative
Details of activity: Chlamydia trachomatis. A small molecule, DS-96, rationally designed for high affinity to Escherichia coli lipid A, was previously demonstrated to bind and neutralize lipopolysaccharide (LPS) from a wide variety of Gram-negative bacteria
Description: Synthetic alkylpolyamine
Institute where first reported: Department of Molecular Biosciences, University of Kansas, Lawrence, Kansas, USA
Year first mentioned: 2008
Highest developmental phase: Preclinical
Development status: Active
Chemical structure(s):
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Molecular weight: 483.86
Iso. SMILES: NCCCNCCCCNCCCNCCCNCCCCCCCCCCCCCCCC
InChI Key: BEBRHYPWEKUKTQ-UHFFFAOYSA-N
Can. SMILES: CCCCCCCCCCCCCCCCNCCCNCCCNCCCCNCCCN
InChI: InChI=1S/C29H65N5/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-22-32-26-19-28-34-29-20-27-33-24-17-16-23-31-25-18-21-30/h31-34H,2-30H2,1H3
External links:
Citations:
  • https://experts.umn.edu/en/publications/pharmacokinetics-of-ds-96-an-alkylpolyamine-lipopolysaccharide-se
  • http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4068484/
  • https://www.ncbi.nlm.nih.gov/core/lw/2.0/html/tileshop_pmc/tileshop_pmc_inline.html?title=Click%20on%20image%20to%20zoom&p=PMC3&id=4068484_zac0061428950001.jpg

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