Compound ID | 2261

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Amycomicin

Class: Natural product antibiotic

Agent Type: Natural product; Small molecule; Direct acting;
Spectrum of activity: Gram-positive
Mechanism of action: Fatty acid synthesis inhibitor
Target Pathogen: Active against Staphylococcaceae; alters fatty acid composition of Staphylococcus aureus
Description: Natural product from a soil actinomycete AA4; decreases murine S. aureus skin infection but acted slower than mupirocin (control)
Year first mentioned: 2018
Development status: Experimental
Chemical structure(s):
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Molecular weight: 351.44
Iso. SMILES: C/C=C/[C@]1([C@@H](O1)[C@H](CCCCC(=O)CCCCCCC(=O)O)O)[N+]#[C-]
InChI Key: AKFABNWZLVRRIF-SVTOFIQFSA-N
Can. SMILES: C/C=C/[C@]1([C@H]([C@H](CCCCC(=O)CCCCCCC(=O)O)O)O1)[N+]#[C-]
InChI: InChI=1S/C19H29NO5/c1-3-14-19(20-2)18(25-19)16(22)12-9-8-11-15(21)10-6-4-5-7-13-17(23)24/h3,14,16,18,22H,4-13H2,1H3,(H,23,24)/b14-3+/t16-,18-,19-/m0/s1
External links:
PubChem link: https://pubchem.ncbi.nlm.nih.gov/compound/146684601
Citation: https://www.pnas.org/doi/10.1073/pnas.1807613115

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