Compound ID | 2262

Update compound information

L-CS319

Synonym(s): D-CS319  |  L-VC26  |  D-VC26

Class: Beta-lactamase inhibitor

Spectrum of activity: Gram-negative
Details of activity: Active against Escherichia coli metallo-beta-lactamases
Description: Synthetic compound (bisthiazolidine); restores beta-lactam susceptibility
Institute where first reported: School of Cellular and Molecular Medicine, Biomedical Sciences Building, University of Bristol, Bristol BS8 1TD, United Kingdom; Facultad de Ciencias Bioquímicas y Farmacéuticas, Instituto de Biología Molecular y Celular de Rosario Consejo Nacional de Investigaciones Científicas y Técnicas de Argentina, Universidad Nacional de Rosario, 2000 Rosario, Argentina
Year first mentioned: 2015
Development status: Experimental
Chemical structure(s):
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Molecular weight: 237.37
Iso. SMILES: C1[C@H](N2[C@@H](S1)CS[C@@H]2CS)C(=O)O
InChI Key: ZTWVMVSSSBGFHH-JKUQZMGJSA-N
Can. SMILES: C([C@@H]1N2[C@@H](CS[C@H]2CS1)C(=O)O)S
InChI: InChI=1S/C7H11NO2S3/c9-7(10)4-2-12-6-3-13-5(1-11)8(4)6/h4-6,11H,1-3H2,(H,9,10)/t4-,5+,6-/m0/s1
External links:
PubChem link: https://pubchem.ncbi.nlm.nih.gov/compound/76936796
Citations:
  • https://pubs.acs.org/doi/10.1021/acs.biochem.5b00106
  • https://pubs.acs.org/doi/10.1021/acsinfecdis.5b00046
  • https://www.pnas.org/doi/10.1073/pnas.1601368113
    • Patent: US10251869B2

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