Auranofin, MMV688978

Class: TrxR inhibitor

Spectrum of activity:	Gram-positive
Details of activity:	Active against replicating and non-replicating Mycobacterium tuberculosis, Staphylococcus aureus, Enterococcus sp., and Neisseria gon; target bacterial flavo enzyme (redox enzyme)
Description:	Synthetic compound from screening pharmacologically active compounds; FDA-approved antirheumatic drug
Year first mentioned:	2015
Development status:	Experimental

Chemical structure(s):
Canonical SMILES:	CC(=O)OC[C@@H]1[C@H]([C@@H]([C@H]([C@@H](O1)[S-])OC(=O)C)OC(=O)C)OC(=O)C.CC[PH+](CC)CC.[Au]
Isomeric SMILES:	CC[PH+](CC)CC.CC(=O)OC[C@@H]1[C@H]([C@@H]([C@H]([C@@H](O1)[S-])OC(=O)C)OC(=O)C)OC(=O)C.[Au]
InChI:	InChI=1S/C14H20O9S.C6H15P.Au/c1-6(15)19-5-10-11(20-7(2)16)12(21-8(3)17)13(14(24)23-10)22-9(4)18;1-4-7(5-2)6-3;/h10-14,24H,5H2,1-4H3;4-6H2,1-3H3;/t10-,11-,12+,13-,14+;;/m1../s1
InChI Key:	IRPYFWIZKIOHQN-XTZHGVARSA-N
Structure link:	https://pubchem.ncbi.nlm.nih.gov/compound/138402869

External links:
Main Source:	https://www.pnas.org/doi/10.1073/pnas.1504022112