Compound ID | 2265
Micasin
Class: Antimicrobial peptide
| Spectrum of activity: | Gram-positive & Gram-negative |
| Details of activity: | Active against methicillin-resistant Staphylococcus aureus, and Pseudomonas aeruginosa; likely has an intracellular target that affects protein folding |
| Description: | Synthetic compound with structure based on defensin from dermatophytic fungus Microsporum canis; no activity against filamentous fungi or yeast (i.e. Saccharomyces cerevisiae); no haemolysis vs mammalian erythrocytes at 50 uM and stable in mouse serum (lethal concentration to bacteria at 0.054 to 23.42 uM) |
| Year first mentioned: | 2012 |
| Development status: | Experimental |
| External links: | |
| PubChem link: | https://pubchem.ncbi.nlm.nih.gov/protein/I1T3C7#section=3D-Structures |
| Citation: | https://www.pnas.org/doi/10.1073/pnas.1201263109 |
| Patent: | CN103421100A |
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