Compound ID | 227

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CL-55

Synonym(s): Fluorothiazinon

Class: Antivirulence agent

Agent Type: Synthetic; Small molecule; Indirect acting; Antivirulence;
Spectrum of activity: Gram-negative
Mechanism of action: T3SS inhibitor
Target Pathogen: Active against Salmonella enterica serovar Typhimurium
Description: Thiohydrazides
Institute where first reported: Gamaleya Research Institute for epidemiology and microbiology, Moscow, Russia
Year first mentioned: 2015
Highest developmental phase: Phase 3 (NCT06815549)
Development status: Active
Chemical structure(s):
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Molecular weight: 133.15
Iso. SMILES: C1=CS(=O)NC(=C1)F
InChI Key: SXIXJFJDCANHIR-UHFFFAOYSA-N
Can. SMILES: C1=CS(=O)NC(=C1)F
InChI: InChI=1S/C4H4FNOS/c5-4-2-1-3-8(7)6-4/h1-3,6H
External links:
PubChem link: https://pubchem.ncbi.nlm.nih.gov/compound/155388053
Guide to Pharmacology: fluorothiazinon
Citations:
  • https://www.nature.com/articles/s41429-022-00504-y
  • http://www.hindawi.com/journals/bmri/2015/484853/abs/
  • https://www.nature.com/articles/s41429-020-00396-w

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