Compound ID | 2275
ZY4
Synonym(s): ZY 4 | ZY-4
Class: Antimicrobial peptide
| Agent Type: | Synthetic; Direct acting; |
| Spectrum of activity: | Gram-negative |
| Mechanism of action: | Membrane-active agent. Permeabilizes bacterial membrane |
| Target Pathogen: | Active against Pseudomonas aeruginosa and Acinetobacter baumannii |
| Propensity to select resistant mutants: | No |
| Description: | Synthetic compound; stable in human plasma, no acute toxicity observed in mice when injected at 40 mg/kg (vs colistin which is toxic at 10 mg/kg); injection of ZY4 in lung infection model suppressed bacterial growth |
| Year first mentioned: | 2019 |
| Development status: | Experimental |
| External links: | |
| Citation: | https://www.pnas.org/doi/10.1073/pnas.1909585117#sec-1 |
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