Compound ID | 2276

Update compound information

Arylfluorosulfate derivative compound 3 (Ar-O-SO2-F)

Class: Small molecule antibacterial agent

Agent Type: Synthetic; Small molecule;
Spectrum of activity: Gram-positive
Mechanism of action: Unknown
Target Pathogen: Active against Staphylococcus aureus, methicillin-resistant Staphylococcus aureus, vancomycin-resistant Staphylococcus aureus, Enterococcus faecium, Staphylococcus epidermidis
Propensity to select resistant mutants: No
Description: Synthetic compound made by Sulfur Fluoride Exchange (SuFEx) click chemistry; has synergistic effect with streptomycin and gentamicin; does not show cytotoxic effect against HEK293T cells; showed comparable activity to vancomycin in an MRSA C. elegans infection model
Year first mentioned: 2021
Development status: Experimental
Chemical structure(s):
Click here for structure editor
Molecular weight: 276.33
Iso. SMILES: OC1=CC(OS(=O)(F)=O)=CC=C1CCCCCC
InChI Key: MKCOEJMCQQFRPH-UHFFFAOYSA-N
Can. SMILES: CCCCCCC1=CC=C(C=C1O)OS(=O)(=O)F
InChI: InChI=1S/C12H17FO4S/c1-2-3-4-5-6-10-7-8-11(9-12(10)14)17-18(13,15)16/h7-9,14H,2-6H2,1H3
External links:
Citation: https://www.pnas.org/doi/10.1073/pnas.2103513118

AntibioticDB is supported by GARDP.

If you have feedback, experience problems, or are interested in a collaboration, please contact us. | Terms and conditions

The content of this site is intended for educational and scientific research purposes only and not as a source of medical advice or consultation.